Caspase-3 Cleavage of GGA3 Stabilizes BACE: Implications for Alzheimer's Disease
نویسنده
چکیده
BACE initiates the production of beta-amyloid (Abeta), the likely cause of Alzheimer's disease (AD). In this issue of Neuron, Tesco et al. show that during apoptosis caspase-3 cleaves the adaptor protein GGA3, which is required for BACE lysosomal degradation, consequently stabilizing BACE and elevating Abeta generation.
منابع مشابه
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ورودعنوان ژورنال:
- Neuron
دوره 54 شماره
صفحات -
تاریخ انتشار 2007